HIGH LEVELS OF ROS IMPAIR LYSOSOMAL ACIDITY AND AUTOPHAGY FLUX IN GLUCOSE-DEPRIVED FIBROBLASTS BY ACTIVATING ATM AND ERK PATHWAYS

High Levels of ROS Impair Lysosomal Acidity and Autophagy Flux in Glucose-Deprived Fibroblasts by Activating ATM and Erk Pathways

Under glucose deprivation, cells heavily mobilize oxidative phosphorylation to maintain energy homeostasis.This leads to the generation of high levels of ATP, as well as reactive toyo proxes st iii 305/40r22 oxygen species (ROS), from mitochondria.In nutrient starvation, autophagy is activated, likely to facilitate resource recycling, but recent st

read more

Particle image velocimetry measurement of complex flow structures in the diffuser and spherical casing of a reactor coolant pump

Understanding of turbulent flow in the reactor coolant pump (RCP) is a premise of the optimal design of the RCP.Flow structures in the RCP, in view of the specially devised spherical casing, are more underwater treasures sunken medallion complicated than those associated with conventional pumps.Hitherto, knowledge of the flow characteristics of the

read more

Tectonic keratoplasty using femtosecond laser lenticule in pediatric patients with corneal perforation secondary to blepharokeratoconjunctivitis: a case report and literature review

Blepharokeratoconjunctivitis secondary to ocular demodicosis in the pediatric population is often neglected and may result in a serious sight-threatening condition.In severe cases, it can lead to underwater treasures sunken medallion corneal perforation necessitating urgent corneal transplantation.However, the shortage and high cost of donor cornea

read more